The aim of the study was to investigate microstructural changes in mouse cranial bone as a result of syndromic craniosynostosis (a congenital craniofacial malformation). Dr Sara Ajami from the team explains "This would enable us to have a better understanding of bone physical quality at different stages of skull development and to determine which microstructural parameters are best suited as biomarkers for prediction, identification and monitoring of craniosynostosis, which would facilitate more effective measurement of treatment outcome and planning."