IBP Network Webinar: Professor Mark Coles and Dr Claire Walsh

Date: 23 March 2022   Time: 15:00 - 16:00

In this special session of the IBP Network Webinar Series, we have invited Professor Mark Coles and Dr Claire Walsh. Each speaker will give a 20 minutes talk, followed by 10 minutes Q&A.

Talk 1: Dr Claire Walsh - Imaging COVID-19 with Hierarchical Phase-Contrast Tomography (HiP-CT): a two year whirlwind

Abstract: HiP-CT Is a new and disruptive imaging technique capable of mutli-resolution, hierarchical imaging of intact human organs down to single cell resolution. The technique was developed at the European Synchrotron Radiation Facility, in response to the COVID-19 pandemic and had been used to provide insight into the patterns of damaged caused by fatal COVID-19 infection. The technique has since been extended, successfully imaging a wide range of human organs including brain, heart, spleen, liver and kidney. This talk will discuss the principles and capabilities of HiP-CT focusing on the BioImage analysis pipelines developed to extract quantitative data from HiP-CT image volumes.

About the speaker: Dr Claire Walsh is a Senior Post-Doctoral Research Fellow working at the UCL Centre for Advanced Biomedical imaging and UCL Department of Mechanical Engineering. See her detailed biography here.

Talk 2: Professor Mark Coles - Multi-modal imaging the foetal origins of human arthritic disease

Abstract: The capacity of the human hand to have fine tool control has been essential in the development of modern humans. Interestingly this is also associated with the development of rheumatoid arthritis which only occurs naturally in humans, and in hands specifically occurs only in the PIP and MCP joints. In contrast osteo arthritis only occurs in the DIP joint. In this talk I will explore the formation of these different joints and why we propose that susceptibility to different arthritic disease in different hand joints occurs as a result of developmental processes. In this talk I will discuss how we have used multimodal imaging and spatial genomics to build a model of joint formation, compare embryonic development to health and disease in adults, developed in vitro joint synovialoids (organoids of the joint) and spatial mathematical model to test hypothesis arising from the human hand joint atlas. Through understanding the physical atlases of tissue formation and function in health and disease promises to help identify new therapeutic approaches for chronic human inflammatory disease.

About the speaker: Professor Mark Coles is a Professor of Immunology at Kennedy Institute of Rheumatology, University of Oxford. See his detailed biography here.

Register here to get the zoom link.

About IBP Network Webinar Series:

  • Open to all IBP Network members. (Not a member? Join here)
  • To bring together members of our community.
  • Talks from eminent scientists, beamline scientists and facility specialists across the world.
  • 30 – 45 minutes talk followed by 5-15 minutes Q&A.
  • Talk will be recorded (except the Q&A) and made available to all network members.

If you wish to suggest a future topic or speaker please contact us, speakers could be from academia, industry, within IBP Network or from further a field.

Location:  Online, Zoom